Nature 380:435–439Ĭhoi K, Kennedy M, Kazarov A, Papadimitriou JC, Keller G (1998) A common precursor for hematopoietic and endothelial cells. Proc Natl Acad Sci USA 95:1641–1646Ĭarmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Genes Dev 11:3286–3305Ĭaprioli A, Jaffredo T, Gautier R, Dubourg C, Dieterlen-Lièvre F (1998) Blood-borne seeding by hematopoietic and endothelial precursors from the allantois. This process is experimental and the keywords may be updated as the learning algorithm improves.Ĭadigan KM, Nusse R (1997) Wnt signaling: a common theme in animal development. ![]() These keywords were added by machine and not by the authors. Vascular Endothelial Growth Factor Gene.Recent evidence, which will be summarized here, suggests that hemangioblastic precursors can be identified based on their expression of vascular endothelial growth factor receptor 2 (VEGFR2). Based on the simultaneous emergence of EC and HC in the blood islands, it was proposed that the two cell types originate from a common precursor, termed hemangioblast. Evidence for blood island formation was initially obtained by observations of living chick blastoderms (Sabin 1920 Murray 1932) (Fig. ![]() They subsequently mature to blood islands, the external cells of which flatten and differentiate into endothelial cells (EC), while the internal cells of the cluster form hemopoietic cells (HC). These aggregates are present at the border of the embryonic and extraembryonic area from the beginning of the second day of the incubation period (around the 1-somite stage). Endothelial and hemopoietic cells of the avian embryonic yolk sac arise from hemangioblastic aggregates, which are clusters of mesodermal cells.
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